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Peptides Are Skin Care’s New It-Thing. Here Are 10 Topicals & Supplements You’ll See (Real) Results With

Gentler than retinoids, these collagen-stimulating skin care saviors can deliver Botox-level before-and-afters: no needles needed.

By Stacia Datskovska Plus Icon

Stacia Datskovska

Senior Commerce Writer for WWD

Recent Articles by Stacia Datskovska

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June 4, 2026, 2:25pm

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a range of the best peptide serums, creams, moisturizers, and supplements over a pale yellow background; best peptide skin care 2026

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Beauty‘s biggest buzzword right now? Peptides, peptides, peptides, repped by dermatologists and age-defying A-listers in equal measure. (Celebrities like the Kardashians, “Her Goopness” Gwyneth Paltrow, and Hailey Bieber, who’s also making peptides the essential building blocks for all her Rhode products, are currently injecting these amino acid chains directly into their faces.)

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Widely referred to as the future of skin care, peptides continue gaining heat in the industry due to their gentle nature — compared to the sometimes burning, redness-inducing retinoids — as well as their ability to boost collagen production, help with elasticity, and cut back on inflammation. Peptides are also present in GLP-1s and athletic recovery powders, but they’re witnessing the most acute popularity surge in the universe of beauty.

And if these distinctions weren’t complicated enough, various kinds of peptides exist within skin care: including signal peptides that stimulate collagen and elastin, carrier peptides that aid in healing and regeneration, and neurotransmitter peptides that toy with muscle contractions to secure that Botox-like look.

As with all trends, there’s been some controversy surrounding the topic… along with some misinformation. Influencers are touting the benefits of peptide injectibles they’ve never tested (but have been paid to advertise) and something called the “Barbie Drug” has prompted thousands of women to pursue a “sunless tan” without fully acknowledging the risks of this particular peptide.

That being said, the safest — and most beginner-friendly — avenue into the realm of peptides involves their topical or supplement manifestations, which promise to remedy the visible signs of aging and optimize skin barrier function.

Tolerated well sans irritation by most users, these peptide types can be easily incorporated into your preexisting routine while bypassing that derm visit. Below, the 10 best peptide serums, creams, masks, balms, moisturizers, and supplements to invest in this month.

Your summertime bucket list will now include achieving more radiant and younger-looking skin, no needles in sight.

Quince Grass-Fed Collagen Peptides Plus Supplement

$28.50 $30 5% off

Buy Now at quince

Our editors’ favorite low-cost luxury bedding and handbag retailer also sells peptide supplements, and this one’s a top-rated, fool-proof way to hop on the bandwagon — requiring nothing more than to be added to your smoothie every morning. The powder is made up of grass-fed, pasture-raised collagen peptides, hyaluronic acid, and vitamin C: precisely what you need to attain glowier, smoother, and more hydrated skin with regular use. Free from major allergens, hormones, GMOs, and anything artificial, the concoction mixes impressively well into coffee and water, too, making it all the more palatable.

The Collagen Peptides Plus Supplement also accommodates Keto and Paleo diets and promotes the strength of hair and nails, all while making sure joints feel supported — no matter your age. The pouch’s 30 servings mean it’s best to take advantage of Quince’s subscription service, which will send you a new peptides package every four weeks. Looking to switch things up? Grab it in chocolate.

What reviewers say: “This collagen powder is fantastic! It dissolves easily, is flavorless, and contains potent ingredients. You can’t beat the price compared to other bestselling brands.”

Price upon publish date of this article: $28.50

Goop Beauty Youth-Boost Peptide Serum

$150

Buy Now at goop

Of course Goop’s seemingly ageless founder, Gwyneth Paltrow, had to come out with her very own take on the peptide trend: in the form of this Youth-Boost Peptide Serum, proven to target the biggest markers of aging skin. Paltrow’s personal review expertly sums up its allure: “I saw a noticeable difference in my skin after trying it for a week, and the results only got better from there. Along with all the visible benefits, I love how moisturizing it is.”

Firming, remedying hyperpigmentation, evening out skin texture, and addressing volume loss, the overachiever harnesses the effects of peptides, yes, but also ingredients like microalgae, black tea ferment, niacinamide, postbiotics, ceramides, and dragon’s blood. (Don’t worry: It’s a plant resin.) Kind to sensitive skin, it can be applied morning and night.

Get back to us in six weeks with your gratitude.

What reviewers say: “Absolutely amazing serum! Makes my skin glow. Also seems to help my makeup go on smoother. Has a nice, clean smell — almost like a boutique hotel.”

Price upon publish date of this article: $150

Medicube PDRN Pink Peptide Serum With Rose PDRN

$18.90 $21.80 13% off

Buy Now at amazon

The best of both worlds (PDRN and peptides, in this case) merge in Medicube’s K-Beauty insider–approved serum that’s been bought over 10,000 times in the past month on Amazon, where it also holds an “Amazon’s Choice” designation. PDRN, the word on everyone’s lips after peptides, is a biological compound made of DNA fragments — typically those taken from salmon. Here, the tissue-repairing and collagen-maximizing heavy hitter is fully vegan, as it’s fueled by rose versus fish extract.

Hand in hand with a five-peptide complex, the PDRN protects skin from pollutants, reinvigorates dullness, mitigates future breakouts, and contributes to replacing fine lines with creaseless luminosity. Plumpness, dewiness, and clarity will be yours to enjoy, and there’s no better time to do so than summer.

What reviewers say: “Deserves 10 stars if that was allowed. I have been using it for a few weeks, and I noticed improvement in my 40-plus skin very quickly. Korean skin care at its finest! My skin is more glowy, bouncy, and hydrated.”

Price upon publish date of this article: $18.90

The Ordinary Multi-Peptide Eye Serum

$25

Buy Now at the ordinary

And if it’s just your eye region that needs a hard reset, turning to The Ordinary’s Multi-Peptide Eye Serum would be a wise choice indeed. The cult-fave beauty destination stands out from the crowd with its clinically backed formulas, manufacturing transparency, and refreshingly affordable price points. This under-$30 gem in The Ordinary’s crown will soon become a lifesaver if you’re on the hunt for a water-based, noncomedogenic topical that tackles everything from crow’s feet to dark circles and puffiness after a long, indulgent night.

Multiple peptide actives come together in the serum to generate elasticity, brightness, and suppleness. Like with all the best things in life, a little goes a long way, so use some moderation when revamping your skin rituals with this highly concentrated innovation.

What reviewers say: “I’ve been using this under-eye serum for years now. Every time I wake up with puffiness under my eyes, I add a thin layer, and about 30 minutes later the puffiness is noticeably gone. The Ordinary never lets me down; I love so many products in this line.”

Price upon publish date of this article: $25

Kate Somerville Peptide K8 Power Cream

$159

Buy Now at kate somerville

Globally recognized celebrity aesthetician Kate Somerville helms an eponymous, clinical-grade skin care company that’s used all over Hollywood. Its offerings cut through the noise by delivering legitimate results you can trust — in turn making those three-figure price tags worth it.

Somerville’s sumptuous peptide cream, pictured above, should be treated as a beauty nonnegotiable: acting on behalf of ceramide-infused peptides, hemp seeds, and humectants that work to decrease wrinkle depth, replenish the skin barrier’s moisture levels, and lead to noticeable firmness.

For a product this hardworking, we’re seriously shocked at just how lightweight and fast-absorbing it is. Dubbed a “graceful aging sidekick,” the cream is meant for your face and décolletage alike, because spreading all that goodness around is the only option.

What reviewers say: “This cream is gorgeous. Very soft and silky on the skin. Sinks in quickly and plays well with others. I wake up to healthy-looking, plumped skin.”

Price upon publish date of this article: $159

Naturium Multi-Peptide Moisturizer

$19.88

Buy Now at amazon

True to its brand’s name, the Naturium Multi-Peptide Moisturizer runs on plants, supplementing their inherently healing capabilities with vitamin C and the hydrating plus inflammation-reducing panthenol. In other words, this budget-conscious buy is a veritable peptide powerhouse and something you’ll find yourself reordering at Amazon almost-religiously. Conditioning skin, ironing out lines, and behaving well under makeup or your go-to SPF, the moisturizer never leaves grease or weight in its wake.

As for that metallic, high-shine packaging? Consider it an instant makeup bag amplifier!

What reviewers say: “This is a very good moisturizer, and it’s scent-free. Many products bother my allergies, but this one doesn’t. Great if you’re sensitive to fragrance in skin care.”

Price upon publish date of this article: $19.88

Enaskin Naturals Salmon PDRN Under-Eye Patches

$21.98

Buy Now at amazon

Hooked on the idea of combining PDRN with peptides in your day-to-day after reading all about the former? Pamper yourself with these under-eye patches that feature both, in a dual-action formulation that deeply permeates the skin and can make you look like you’ve gotten eight hours of sleep after a red-eye (these caffeine-containing babies are nothing if not travel-ready). The eye masks constrict dilated vessels, give off a cooling effect you’ll oh-so-appreciate if you pop them in the fridge ahead of time, and are ergonomically shaped enough to double as “smile line patches,” per the brand.

Thirty pink pairs come with each purchase, so go ahead and make a girls’ night out of it.

What reviewers say: “A quick fix for tired eyes. They feel cooling and soothing right away and actually stay in place while you wear them. After about 15–20 minutes, my under-eye area looks more hydrated and less puffy. They do make a difference, especially in how makeup applies afterward. The serum absorbs well and doesn’t irritate my sensitive skin.”

Price upon publish date of this article: $21.98

Perricone MD Neuropeptide Pro-Strength Firming Moisturizer

$189

Buy Now at perricone md

Perricone MD’s holistic wellness approach was pioneered by Dr. Nicholas Perricone, board-certified dermatologist and nutritional expert. A crucial component of his system: potent skin care solutions that don’t make promises they can’t keep. This luxury moisturizer is case in point — honing in on your deepest, most stubborn creases by way of neuropeptides and bounce-bestowing growth factor peptides. Swiss apple stem cells (an industry darling) also have a starring role, nursing fragile, crepey complexions back to full strength. Spent too long in the sun back in the day and can’t seem to get rid of the subsequent photodamage? You’re looking at the cure.

A rose bergamot scent seals the deal on this being one of the best investments you can make for the well-being of your skin.

What reviewers say: “I didn’t expect to love this as much as I do. It’s super moisturizing but somehow doesn’t feel heavy or greasy (which is rare for me), and my skin just LOOKS better. Like smoother, firmer, and more ‘put together’ even when I’m not.”

Price upon publish date of this article: $189

Lemme Starface Healthy Skin Gummies

$29.99

Buy Now at target

Part sweet treat and part skin-health restorer, this gummy rollout from Kourtney Kardashian’s brand Lemme is perhaps the most satisfying way to integrate peptides into your lifestyle. It’s a fresh release, as part of Lemme’s collaboration with pimple-patch giant Starface this May, and has already taken social media by storm. We have to make one thing very clear, though: The Lemme x Starface Healthy Skin Gummies are not all buzz and no bite.

On the contrary, they leverage vitamins to fight oxidative stress, create a “glowing from within” appearance courtesy of collagen peptides, and increase cell turnover rates with zinc. Lemon balm, meanwhile, grants further antioxidant magic and a taste you’ll be looking forward to each time you wake up.

Two star-shaped gummies a day is all it takes to spot a difference, not overnight but still much quicker than you’d expect.

What reviewers say: “Delicious lemon flavor. The stars are so cute! I really like the clean ingredients, too.”

Price upon publish date of this article: $29.99

Rhode Peptide Lip Treatment

$20

Buy Now at rhode

The Peptide Lip Treatment from Rhode is practically ubiquitous at this point, continuing to reside on the back of It-girls’ phone cases while seeing its fair share of online hype. But did you know the Bieber-ideated balm is also one of the top peptide treatments for lips on the market? This area of the face tends to be overlooked when talk of aging comes up, but it actually suffers as much as your forehead — evidenced in deflated Cupid’s bows, vertical lip lines, and other pesky problems.

Rhode’s $20 miracle maker comes in to save the day, and make you smile wide again, by locking in hydration, blessing lips with a “pillowy-soft” sensation, and swapping dryness for covetable glossiness and cellular-level nourishment. Swipe it on whenever needed and use it as an excuse to relish Rhode’s most popular scents of the season — from vanilla to watermelon.

What reviewers say: “The formula feels way smoother and more nourishing than Vaseline or Aquaphor to me. It keeps my lips soft for hours, gives the prettiest glossy look, and doesn’t feel like a burden. Definitely one of the best lip treatments I’ve tried in a long time.”

Price upon publish date of this article: $20

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Meet the Author

Stacia Datskovska is a Senior Commerce Writer at WWD. Previously, she worked at ELLE DECOR as an assistant digital editor, covering all things luxury, culture, and lifestyle through a design lens. Her bylines over the past five years have appeared in USA Today, Baltimore Sun, Teen Vogue, Boston Globe, Food & Wine, and more. Prior to joining ELLE DECOR, Datskovska learned the ins and outs of e-commerce at Mashable, where she tested products, covered tentpole sales events, and curated gift guide roundups. She graduated from NYU with a bachelor’s degree in journalism and international relations. Datskovska regularly reports on today’s biggest skin care trends that are actually worth the investment.

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Peptides Are Skin Care’s New It-Thing. Here Are 10 Topicals & Supplements You’ll See (Real) Results With

Recent Articles by Stacia Datskovska

10 Best Peptide Skin Care Products to Buy Online

Quince Grass-Fed Collagen Peptides Plus Supplement

Goop Beauty Youth-Boost Peptide Serum

Medicube PDRN Pink Peptide Serum With Rose PDRN

The Ordinary Multi-Peptide Eye Serum

Kate Somerville Peptide K8 Power Cream

Naturium Multi-Peptide Moisturizer

Enaskin Naturals Salmon PDRN Under-Eye Patches

Perricone MD Neuropeptide Pro-Strength Firming Moisturizer

Lemme Starface Healthy Skin Gummies

Rhode Peptide Lip Treatment

Related Articles

Quince Grass-Fed Collagen Peptides Plus Supplement

Goop Beauty Youth-Boost Peptide Serum

Medicube PDRN Pink Peptide Serum With Rose PDRN

The Ordinary Multi-Peptide Eye Serum

Kate Somerville Peptide K8 Power Cream

Naturium Multi-Peptide Moisturizer

Enaskin Naturals Salmon PDRN Under-Eye Patches

Perricone MD Neuropeptide Pro-Strength Firming Moisturizer

Lemme Starface Healthy Skin Gummies

Rhode Peptide Lip Treatment

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